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TMS Therapy for Partial-Responding Patients

Who is a Partial Responder?

Patients who have experienced response following antidepressant therapy but who still have symptoms of depression and no longer show any further sign of improvement after an extended period of treatment

3 x

Patients with residual symptoms of depression are three times more likely to relapse 1

33-67%

Remission rates (using QIDSSR16) were 37% after first trial, reaching only 67% after 3 more trials (cumulative) 2

5.5 x faster 

Patients with residual symptoms relapsed to next depressive episode 5.5 times faster than patients treated to remission (p<.0001) 3

1/4 patients

Discontinue antidepressants due to difficult-to-tolerate
side effects 4

Transcranial Magnetic Stimulation (TMS) is cleared by the U.S. Food and Drug Administration (FDA) for major depressive disorder (MDD) in patients who have not responded to 1 adequate antidepressant trial in the current episode. 


Studies have found the following TMS therapy rates:

  • 62% response 5
  • 41% remission 6
  • 62.5% durability 7




(1) Paykel ES et al. Psychol Med 1995; 25: 1171-1180 (2) STARD Rush et al. Am J Psych 2006;163(11):1905–1917 (3) Judd LL et al. J Affect Disord 1998; 50 (2-3): 97-108 (4) Kelly et al. Dialogues Clin Neurosci 2008; 10(4):409–418 (5) Dunner et al., J Clin Psychiatry 2014, PMID 25271871. (6) Ibid. (7) 12-mo follow-up measured via IRS-SR scale with a cohort of 120 patients


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